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Description: The Paladini Lab, a part of the University of Texas at San Antonio Neurosciences Institute, researches the dopaminergic (DA) neurons of the ventral mesencephalon that are a part of a pathway that regulates reward-seeking behaviors and are the principal cells affected in Parkinson's Disease and addiction. Many drugs of abuse exert dysregulating effects on levels of dopamine and other neurotransmitters, resulting in widespread effects on DA neuron firing pattern. Psychostimulants (e.g., cocaine and amphetamine) alter interactions among multiple receptor subtypes that are co-expressed on DA neurons. Changes in DA neuron activity secondary to altered receptor interactions may underlie many of the behavioral changes associated with drug addiction independently of natural reward seeking mechanisms like feeding. The projects in the lab are funded by the National Institute on Drug Abuse (DA016262), the National Institute of Mental Health (MH079276), and the National Institute of Neurological Disorders and Stroke (NS060658).
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Subject: Dopaminergic neurons., Parkinson’s disease. , Addictive behavior., University of Texas at San Antonio Neurosciences Institute.
Creator: Paladini Research Lab
Publisher: University of Texas at San Antonio
Language: English
Coverage: San Antonio (Tex.)
Format: Mixed
Type: Interactive resource
Date: 2009-2018
Identifier: 00202
Collector: University of Texas at San Antonio Archives and Special Collections
Description: University of Texas at San Antonio Basal Ganglia Anatomy, Physiology and Computation Lab studies the circuitry and neurons of the basal ganglia, with the goal of understanding the computational function of these structures at the cellular level, and their dysfunction in diseases, especially Parkinson’s Disease. Experiments are focused on the ionic mechanisms that endow each cell type with its characteristic responses to synaptic input, the patterns of connectivity that deliver specific inputs to each cell, and the dynamics that arise from the combination of these.
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Subject: Parkinson’s disease. , Neurosciences., University of Texas at San Antonio. Department of Biology., University of Texas at San Antonio. Basal Ganglia Anatomy, Physiology and Computation Lab., Basal ganglia.
Creator: University of Texas at San Antonio Basal Ganglia Anatomy, Physiology and Computation Lab
Publisher: University of Texas at San Antonio
Language: English
Coverage: San Antonio (Tex.)
Format: Mixed
Type: Interactive resource
Date: 2009-2021
Identifier: 00175
Collector: University of Texas at San Antonio Archives and Special Collections
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