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Description: 3D Tune-In brings together relevant stakeholders: the SME digital games industry (Reactify, Vianet, XTeam and Nerlaska);
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Coordinator: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Country: United Kingdom
Description: Cancer is a major health problem worldwide, being the most common cause of death after cardiovascular diseases. The major goal of new anticancer therapies is to specifically kill tumour cells while leaving healthy cells unharmed. A main challenge to achieve this aim is the development of better drugs, including novel treatments based on the use of siRNAs. These macromolecules are potentially the most powerful anti-cancer drugs that exist, but still there is no efficient way of getting them delivered specifically to the tumour. Indeed, lifetime of such molecules is generally too short and therefore need to be protected in a carrier until they are delivered into tumour target cells.
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CountryCode: UK
Coordinator: THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country: United Kingdom
Description: An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat RNA is transcribed and accumulates in neuronal RNA aggregates, implicating RNA toxicity as a key pathogenic mechanism. However, the pathways that lead to neurodegeneration are unknown. My lab has made pioneering contributions to the understanding of C9orf72 FTD/ALS, and reported the first structure of the repeat RNA, and the first description of both sense and antisense RNA aggregates in patient brain. We have now developed new disease models that allow, for the first time, the dissection of RNA toxicity both in vivo and in sophisticated neuronal culture models. We have also used our knowledge of the repeat structure to identify novel small molecules that show very strong binding to the repeats. We will utilise our innovative disease models in a multidisciplinary approach to fully dissect the cellular pathways underlying C9orf72 repeat RNA toxicity in vivo, on a genome-wide scale. Altered RNA metabolism has been implicated in a wide range of neurodegenerative diseases, indicating that our findings will provide profound new insight into fundamental mechanisms of neuronal maintenance and survival. This research programme will also deliver a step change in our understanding of C9orf72 FTD/ALS pathogenesis and provide essential insight for the identification of small molecules with genuine therapeutic potential. RNA-mediated mechanisms are now known to be a common theme in neurodegeneration, suggesting these findings will have broad significance.
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Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: I intend to travel to the University of Oxford and the lab of Dr. Moritz Riede and build a second generation version of the
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Cell therapy has shown promising results for treating and curing a large range of diseases, from cancer to diabetes. The principles of cell therapy are easy to describe: cells (possibly modified) are injected into patients. Cell therapy is now a reality in Europe: in August 2018 the first two treatments for patients with blood cancer were approved; more of them are about to successfully conclude the approval path. What hinders the large-scale uptake of cell therapy is its costs: culturing enough cells of high quality requires specialised personnel and infrastructure, which only a few centres can afford. The market asks for a scalable cell culture platform that can produce large quantities of high quality cells at much lower costs than done nowadays. To address this need, we have developed the Facer – the first fully-autonomous cell culture platform. The Facer can manufacture billions of high-quality cells starting from the small quantity (about 500,000 cells) of a tissue biopsy without the need of human intervention, thanks to a unique patented iterative process. Our product is at TRL 7; its performances, in terms of quality and costs, are superior to any competitor commercially available. We have developed the Facer over the course of 5 years thanks to cash investments of over €3 million. In the Phase 2 project we will finalise the product, perform a validation with external partners, gain the CE marking (our product is not a medical device), and find a distributor and a launching customer. We will initially tackle the European market to then expand globally once that the local regulatory barriers are overcome. In 2024, after 5 years from the first sale, our turnover will surpass the €60 million and our EBITDA will be over €36 million. Our innovation can enable affordable cell therapies at a large scale and change the life of millions of patients who suffer from diseases that have been deemed 'incurable' so far.
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Description: Social interactions are ubiquitous and our globalized society challenges us with increasingly complex social environments. Yet, evolution has equipped humans with a unique capacity to navigate our social worlds, namely the capacity for rhythmic interpersonal coordination. Despite its relevance, social neuroscience studies have largely ignored this phenomenon, due to methodological constraints inherent in the nature of social interaction. In light of new technological advancements, however, the overarching aims of the proposed project are: (1) to implement an interdisciplinary psychological and neuroscientific approach and a novel experimental methodology that combines Virtual Reality (VR) and functional Near-Infrared Spectroscopy (fNIRS), in order to (2) understand how social interaction is both expressed in and shaped by rhythmic interpersonal coordination on both a behavioural and a neural level, and to (3) determine whether individuals with autism spectrum disorder (ASD) and typically developed individuals differ in their capacity to rhythmically coordinate their motor actions. Thus, the proposed interdisciplinary project combines social psychology research with technical virtual reality innovations and envisages behavioural (synchroneous tapping paradigm), neuroimaging (fNIRS) and clinical (ASD) implementations. It will result in a high-quality scientific programme with long-term potential, by laying the groundwork for the adoption of the concept of “Social Interaction Rhythms” in social neuroscience.
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Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: This ETN is embedded into an established international research programme; The European Research Initiative on Anaplastic Lymphoma Kinase (ALK)-related malignancies (ERIA; www.erialcl.net) is an existing and functional network of 13 partners, which will cosset and nurture a cohort of early stage researchers to become confident, competent, independent and well-connected European scientists with excellent career perspectives. ERIA was instigated to coordinate research into ALK-related malignancies to facilitate the development of less-toxic and more efficacious therapies. ALK is increasingly recognised as a prevalent oncogene in a number of human malignancies and therefore poses a prominent clinical problem, which requires coordinated research into its oncogenic mechanisms. ERIA now conducts a collaborative multidisciplinary research programme at the interface of biomedical and bio-mechanistic approaches, which will be an excellent environment to train the next generation of European scientists. The 15 recruited fellows will be incorporated into international academic study groups (all partners of the ERIA network) to perform high calibre research and also will be exposed to environments from other sectors to broaden their experience. Secondments will include technical training within individual laboratories and SMEs (TissueGnostics, Galkem, Cambridge Life Sciences, Sofigen and Varionostics) as well as large Pharma (Roche). Training through research will be complemented with a balanced programme of transferable skills and access to local courses. The training of each fellow will be guided by a personal career development plan and supervised by a PhD committee panel. The primary goal of the network is to train the recruited fellows by participation in an internationally competitive research programme and integrating them into an international network. Thereby providing competence in state-of-the-art research and development at the forefront of translational science.
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Coordinator: THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country: United Kingdom
Description: This research project focuses on several key Direct Energy Deposition (DED) Additive Manufacturing (AM) processes that have great potential to be used as cost-effective and efficient repairing and re-manufacturing processes for aerospace components such as turbine blades and landing gears. This project aims to conduct fundamental research to understand the material integrity through chosen DED AM processes, the accuracy and limitations of these deposition processes, effective defect geometry mapping and generation methods, and automated and hybrid DED and post-deposition machining strategies. This project intends to connect repair and re-manufacturing strategies with design through accurate DED process simulation and novel multi-disciplinary design optimisation (MDO) methods to ultimately reduce the weakness of aerospace component at design stage and prolong their the lifecycles. Both powder-based and wire-based DED systems will be investigated to establish an across-the-board comparative study. The data collected through this comprehensive comparative study will be extremely valuable for the OEMs of this project (i.e. GKN, PWC, and HDI) to understand the pros and cons of these DED systems and will help them to select suitable repair and re-manufacturing strategies. The tests conducted in this research are also extremely beneficial for the SMEs in this project (i.e. Liburdi, AV&R, DPS) to validate their existing repairing systems and techniques.
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Group: Projects completed before 1 January 2021
Coordinator: THE UNIVERSITY OF SHEFFIELD
Country: United Kingdom
Description: The stereoselective synthesis of small organic molecules depends on robust catalytic methods. Despite many advances in enantioselective synthesis, an unsolved challenge in catalysis is the translation of enantioselective catalytic reactions to diastereoselective reactions – where a chiral catalyst controls the outcome of reaction of a chiral substrate.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: THALES will embed archaeological data from two excavation projects on the Milesian peninsula, Turkey, into wider discourses on economic production, landscape change and philosophical reflection in the Greek world between the 8th and 6th centuries BC. The archaeological finds from the Temple of Didyma and the nearby necropolis of Panormos (harbour of Didyma) provide vital information about the economy and ritual traditions of this lynchpin region of the Greek and Mediterranean world during a pre-modern era of 'globalisation'. The project will stimulate a transformation in the study of the early classical world with the application of state-of-the-art spatial theories to the landscape around these sites and an innovative combination of quantitative analysis to finds from both excavations, set against the context of contemporary scientific endeavours indexed by the earliest European philosophers writing in Ionia (most famous being Thales of Miletos). The high quality, multidisciplinary research results will contribute significantly to our knowledge of this formative phase of European cultural and intellectual foundations, provide cross-fertilization between disciplines and develop the Experienced Researcher’s long-term vision of modernising classical scholarship.
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Coordinator: THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country: United Kingdom
Description: The aim of personal robotics is to design companion robots that can live and interact with people in a very intuitive way. This requires designing robots that are capable of adapting to the human users, via learning during interaction. This proposal aims at the timely establishment of the first European Industrial Doctorate in “Applications of Personal Robotics for Interaction and Learning” (APRIL) to train future researchers and engineers for the emerging field of personal robotics. APRIL strategically adopts a key entrepreneurial ethos which will equip PhD students with radical cross-sector and interdisciplinary skills and mind-set, by combing research on developmental and social cognitive systems with hands-on experiments on the application of human-robot interaction and assistive systems. APRIL is the result of the strategic synergies of Plymouth University Centre for Robotics and Neural Systems with its international leadership and reputation as UK and European hub in cognitive developmental robotics and human-robot interaction, and with Aldebaran Robotics A-Lab R&D Division which has the world leading market position in the personal robotics industry with the robots NAO and Pepper. This is complemented by six international partners from industry (SONY Corporation, MetraLabs GmbH), academia (Osaka, Humboldt Berlin) and robot users (San Raffaele Hospital Milan and SSSA DomoCasa Pisa). The doctoral training strategy of the EID will implement the latest innovative PhD training approaches of situative and social constructivist learning theories with a unique Coaching Programme for a tailored Individual Skills Development Plan, peer-support and student-centred cohort activities, as well as a strong leadership skills programme for continuous professional development. The two beneficiaries will contribute with a pool of over 12 academic and industry supervisors and will fund 5 additional PhD bursaries to match the EID cohort of the 5 Marie Skłodowska-Curie funded ESR
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Coordinator: UNIVERSITY OF PLYMOUTH
Country: United Kingdom
Description: The global population recently surpassed 7 billion and is projected to reach 9.8 billion by 2050. Food demand
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Coordinator: ARBOREA LTD
Country: United Kingdom
Description: The ARIA-VALUSPA project will create a ground-breaking new framework that will allow easy creation of Artificial Retrieval of Information Assistants (ARIAs) that are capable of holding multi-modal social interactions in challenging and unexpected situations. The system can generate search queries and return the information requested by interacting with humans through virtual characters. These virtual humans will be able to sustain an interaction with a user for some time, and react appropriately to the user's verbal and non-verbal behaviour when presenting the requested information and refining search results. Using audio and video signals as input, both verbal and non-verbal components of human communication are captured. Together with a rich and realistic emotive personality model, a sophisticated dialogue management system decides how to respond to a user's input, be it a spoken sentence, a head nod, or a smile. The ARIA uses special speech synthesisers to create emotionally coloured speech and a fully expressive 3D face to create the chosen response. Back-channelling, indicating that the ARIA understood what the user meant, or returning a smile are but a few of the many ways in which it can employ emotionally coloured social signals to improve communication.
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Coordinator: THE UNIVERSITY OF NOTTINGHAM
Country: United Kingdom
Description: Gastroesophageal Reflux Disease (GERD) is a digestive disorder associated with symptoms such as heartburn and regurgitation, and reflux of normal gastric content like gastric acid and digestive enzymes. GERD is caused by a loss of integrity of the gastro-esophageal barrier known as the 'lower esophageal sphincter' (LES). This condition is one of the most common gastroenterological diagnosis in the European Union, with an estimated 15-20 Million daily sufferers. GERD today is typically treated with medications such as proton pump inhibitors (PPIs). Unfortunately, these anti-acid medications only ‘mask’ GERD symptoms, cause severe side-effects long-term, and about 20% of patients are non-responders. Importantly, they do not treat/cure the underlying root cause of acid reflux. For people who have severe GERD and do not respond to
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Coordinator: ASCENTX MEDICAL EUROPE LIMITED
Country: United Kingdom
Description: The need for improved food production for the growing population has led to increase in planet’s arable land cover. Many studies suggest that such practices lead to loss of soil organic carbon (C) – a relatively large C pool with a fast response time. Thus there is a need to manage soils sustainably in order to mitigate atmospheric CO2 levels while maintaining agricultural productivity. Soil microorganisms act as gatekeepers for soil-atmosphere C exchange by regulating the storage and release of organic C in soil. However, there is a lack of understanding on how land use induced shifts in soil microbial diversity affects this regulation; necessitating detailed research on the underpinning microbial mechanisms. The project objective is to discern the effects of land use on microbial diversity in differing soil types and to investigate whether this shift has implications for C cycling (do certain microbial groups have a greater capacity for soil C accumulation?). To address these objectives an interdisciplinary approach merging molecular biology and isotope chemistry will be employed. Soil from long-term grassland-arable paired sites will be used to assess differences in microbial biodiversity and functional gene abundance through DNA next-generation sequencing. In addition, a field incubation experiment with 13C labelled substrates will be performed to investigate the variable tracer incorporation into different microbial functional groups. This will be measured using novel magnetic bead capture hybridization of RNA from specific groups followed by its 13C analysis using liquid chromatography-isotope ratio mass spectrometry. The novelty of this project is that it aims to provide direct evidence to prove diversity-function linkages and gain mechanistic understanding of the physiological responses of soil microbial communities to land use change. The resulting knowledge will help better predict changes in soil C and thus improve prognosis of climate change feedbacks.
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Coordinator: UNITED KINGDOM RESEARCH AND INNOVATION
Country: United Kingdom
Description: MACC-III is the last of the pre-operational stages in the development of the Copernicus Atmosphere Service. Its overall institutional objective is to function as the bridge between the developmental precursor projects - GEMS, PROMOTE, MACC and MACC-II- and the Atmosphere Service envisaged to form part of Copernicus Operations.
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Coordinator: EUROPEAN CENTRE FOR MEDIUM-RANGE WEATHER FORECASTS
Country: United Kingdom
Description: This proposal describes the 3D printing of hydrogel droplet networks to prepare artificial tissue-like materials that demonstrate stimulus-responsive chemo-mechanical actuation. A recent breakthrough by Prof. Bayley’s research group has enabled the 3D printing of self-supporting droplet networks which can be functionalised to allow rapid electrical and molecular communication along a specific path. As a result of this, an opportunity now exists to prepare tissue-like materials that can perform mechanical work in response to external stimuli. By printing biocompatible and responsive polymer hydrogels into droplet networks, artificial muscles will be prepared that display specific and well-defined motion. The resulting technology will be of great importance for a variety of biomaterial applications, with future European Union (EU) industrial growth as well as the public ultimately benefiting from progress in this area.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: BEACONING sets a forefront in multifaceted education technologies through large-scale piloting of a digital learning platform that blend physical and digital spaces. As innovation action strategies, pilots combine opportunities for new ICTs in multiple ways that merge learning acquired in formal, non-formal and informal means, developing the skills for today’s abled and disabled learners and workforce. The BEACONING platform will be a ubiquitous solution that exploits advances in user experience design, mobile communication, location-based and context aware systems, procedural content generation, pedagogy-driven gamification, learning analytics and cloud technology though innovative integration towards a blended learning space. The BEACONING demonstrator will facilitate, assess and author gamified learning activities, integrating existing educational tools and services of the participating organisations. Focusing on STEM (Science, Technology, Engineering and Mathematics), the cross-subject approach embedded in a Problem-Based Learning model will contextualise learning within real world problem solving and applications. The role of learners is amplified in the process of filtering and connecting concepts framed under practical, investigative and exploratory scenarios. Large-scale pilots will validate and inform the development of the BEACONING ecosystem that democratises learning across and among fully abled and those with mild to moderate physical and mental impairments (age 15 to 24), undergoing general and vocational training. BEACONING anticipates the benefits of making cross-subject matter more understandable, fostering the application of subject specialism to other domains. The pilot substantiates the technical and economic viability and the impact of the innovative platform to strategise market adoption and replication. By integrating experiences in a highly engaging, contextualized and personalised manner, learning can beyond the barriers of space and time.
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Coordinator: COVENTRY UNIVERSITY
Country: United Kingdom
Description: As DNA testing is most commonly centralised in labs, it lacks the turnaround time for time-sensitive applications, and also lacks mobility. The experience in biology required to prepare samples and carry out testing obfuscate the process and limit point-of-care applications. Biomeme seeks to break down these barriers with their versatile Dx System, a holistic solution to bring DNA testing out of the labs and into the physician’s office. Thus, Biomeme provides Molecular Diagnostics for the on-demand economy. By simplifying the process of DNA testing, without sacrificing the detail to be found in raw data, the Biomeme solution brings molecular diagnostic into point-of-care medical services, making it available for homecare and other point-of-need uses.
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Coordinator: BIOMEME UK LTD
Country: United Kingdom
Description: Algal biofuels have the potential to provide a sustainable carbon-neutral source to fossil fuels, however the scaling up of algal systems is economically challenging. Here we propose a bio inspired approach to exploiting light-matter interaction by understanding and mimicking the optical properties of corals. We aim to inspire the development of improved photonic materials that can be used to maximise algal growth in order to radically transform the algal biofuel sector. The specific objectives are to 1) explore the in vivo light field, optical properties and photosynthetic efficiency of a range of coral species from different light regimes, 2) understand the nanophotonic and structural properties of corals underlying the optimised light modulation and 3) apply the biophotonic insight to design novel photonic materials for the improved growth of microalgae. The proposal is highly interdisciplinary involving optical and photonic characterisation, photosynthesis research and the fabrication of novel materials. The successful implementation of this project will have a high societal impact, through improving the biofuel sector and working towards carbon-neutral fuel sources.
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Coordinator: THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country: United Kingdom
Description: Eusociality, in which workers sacrifice their own reproduction to rear the offspring of queens, is a major focus of interest in evolutionary biology. A key aim during recent decades has been to understand the conflicts of interest within eusocial groups. In contrast, however, little is known about the underlying genetic architecture. In this proposal, we will use a mixture of field experiments and transcriptomics to address novel questions about the evolutionary dynamics of queen-worker interactions. Borrowing concepts from the field of sexual conflict, we will investigate a new idea: that the productivity of social groups is limited because castes are constrained by inter-caste genetic correlations from simultaneously reaching their optimal (dimorphic) phenotypes. We will also quantify caste dimorphism across an environmental gradient, and investigate the plasticity of dimorphism using transplants and social manipulations. In addition, we will cross-foster individuals between nests to test for coadaptation between queens and workers. And we will test a long-standing hypothesis experimentally for the first time: that queens manipulate worker phenotype in their own interests.
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Coordinator: THE UNIVERSITY OF EXETER
Country: United Kingdom
Description: The level of polyandry is a key trait influencing population dynamics and inter-sexual interactions of organisms. In nature, females of some species mate only once in their life time, whereas others mate with multiple males. My research aims at understanding why there is so many variation in the level of polyandry. I will tackle this question by focusing on female immune function. Mating can up-/down-regulate immune function, which is likely to inflict fitness costs on females if they mate with multiple males. If the level of polyandry positively correlates with the efficiency of female immune function, immune function may compensate for the costs of multiple mating. To test this hypothesis, I will use 25 isolines of the fruit fly Drosophila pseudoobscura that genetically differ profoundly in their predisposition to polyandry. This unique system will allow me to examine effects of both mating and genetic variation in polyandry on female immune function. This project will complement my current research that to date has focused on specific applied agricultural-pest systems. I have less experience working on explicitly evolutionary-focused questions, so this research programme will provide an additional dimension to my applied research. Prof Wedell is a leading scientist in the field of experimental evolutionary biology, and is the perfect person to expand my horizons into more conceptual and broader ideas. Under her mentoring, I will be able to develop my own research and skills in proposal writing and teaching. The new knowledge, skills and techniques that I will acquire through the project will feed back to my previous work on agricultural pests, which will result in me being able to bridge the gap between model organism and agricultural pest systems. The unique situation will enable me to develop a unique line of research in both evolutionary and applied biology. Ultimately, this Fellowship will put me in an excellent position for my further career.
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Coordinator: THE UNIVERSITY OF EXETER
Country: United Kingdom
Description: Wind energy is one of the fastest growing sectors in the world's energy markets. According to the EWEA, the European wind market it is expected to grow consistently at a compound annual growth rate of 9.8%. As annual blade failures are estimated at around 3,800 with poor maintenance the most common cause of accidents, ensuring the integrity of blades is a key issue with respect to the business, safety and the environment. The overall problem envisaged is the lack of effective condition monitoring systems for the blades, representing a business opportunity for the project’s partners Hence, the Project aims to commercialize a novel solution, BladeSave, marketed as a fusion between a Fibre Optic Structural Health Monitoring System providing multi-sensing capability and a management software incorporating risk based inspection data analysis and offering a comprehensive solution for blade monitoring, repair and management. Based on existing technologies developed by the partners at TRL6, BladeSave will assist WFOs in satisfying newly imposed regulations by the European Agency for Safety and Health at Work (amendments to EN 50308) and benefit European ISPs in the CM services market, giving them a competitive edge over global rivals. Our product market target consists predominantly of the WTFs installed before 2011 (currently around 71,620 in Europe) as old wind turbines have an average annual maintenance cost larger than newer models, are not covered by warranties and offer a bigger risk of catastrophic failures. The project brings together five experienced companies with a unique set of skills and expertise in the wind industry. BladeSave will have an impact on both European and foreign markets, and over the five year sales projection, we forecast a total cumulative gross profits of at least €48 million, a return of EU investment of 23:1 and the creation of about 380 jobs within consortium and associated companies which are part of the supply chain.
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Group: Projects completed before 1 January 2021
Coordinator: RENEWABLE ADVICE LTD
Country: United Kingdom
Description: Dengue virus (DENV) is the most prevalent arthropod-borne viral pathogen and infects about 400 million people worldwide
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Group: Projects completed before 1 January 2021
Coordinator: CARDIFF UNIVERSITY
Country: United Kingdom
Description: Multinational Enterprises (MNEs) are key ‘tectonic forces’, shaping the ‘mountains’ in a far-from-flat world economic geography. In 2010, MNEs generated value added for approximately US$16 trillion accounting for more than a quarter of world GDP (UNCTAD, 2012). The progessive expansion of firms from emerging economies into multinational enterprises is unprecedented. Outflows of FDIs from developing economies reached the record level of $426 billion in 2012, corresponding to 31% of global outflows, up from 16% in 2007 (UNCTAD, 2013).
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Coordinator: LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE
Country: United Kingdom
Description: 'ERIN offers a network analysis, investigating the cultural articulation of national identity in 19th-century Europe as found in the musical works of Irish poet-songwriter Thomas Moore. He created two European song series, the Irish Melodies and National Airs, of global circulation; these inspired arrangements by European composers. His epic poem Lalla Rookh inspired operas and ballets. ERIN is the first systematic study of this cultural network, and innovative in considering the temporal and spatial aspects of networking. ERIN contributes to the knowledge-based economy and society through accessible research outputs designed to engage the European public: an online forum, a podcast, a radio show, an interactive online exhibit, a database, an edited book. ERIN's research foundation is the substantial Moore collection at host Queen's; a database of its and other's Moore holdings becomes a dataset to be mined for the remaining outputs. The researcher will establish a network between herself, Queen's and selected European libraries in the process of preparing the database and the online exhibition. The researcher acquires skills that enhance her intersectoral mobility within Europe by observing a carefully-chosen training programme at Queen's that will also benefit ERIN's project outcomes. This training will also prepare her for an intended media secondment. By leading ERIN, the researcher will gain project management skills and gain valuable intersectoral contacts. Through leadership, networking, and training, the researcher will be involved in knowledge transfer. She will build on her existing experience as a contributor to several significant bibliographical and historiographical projects; the MSC fellowship will enable her to assume a position of leadership in the scholarly community (or in the media) while enhancing her creativity. Queen's enjoys 'HR Excellence in Research Status' and offers the researcher a stimulating interdisciplinary research environment.'
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Coordinator: THE QUEEN'S UNIVERSITY OF BELFAST
Country: United Kingdom
Description: In morpho-phonological alternations the shapes of morphemes differ between morphologically related word forms. In these alternations the morphological environment is also implicated (revére ~ réverence verb [iː] ~ noun [ɛ] and stress differ) unlike alternations which are conditioned only by the phonological environment.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Environmental factors, including the heavy metal mercury, are recognized as having a dominant influence on the aetiology and prevalence of neurodevelopmental behavioural disorders. This proposal will develop a new model for assessing the role of gene:environment interactions, specifically genetic predisposition for toxicity, in risk for disease, and identify early markers predictive of toxicity and later phenotypes. This will directly relate to the EC work program for Health, demographic change and wellbeing, with respect to both 'Personalized medicine' for non-communicable diseases and 'Early development' addressing mental health from childhood to older ages. The project uses the zebrafish model to investigate the relationship between glutathione-S-transferase (GST)-related genetic background, developmental exposure to mercury, and risk for neurodevelopmental disorders. This will be achieved by exposure of wild-type and CRISPR-generated Gst mutant embryos to mercury, and testing whether genetic predisposition leads to increased risk for toxin-induced behavioural phenotypes. We will test for altered biochemical, transcriptomic and epigenomic modifications that may serve as potential early markers for insult. The results obtained in this proposal will have significant impact on the ability to conduct individual and population specific toxicity risk assessment, and may lead to novel measures for early detection of increased risk and alleviation of potential adverse outcomes. The high-quality original research presented in the proposal will not only enable the Experienced Researcher to reach a position of professional maturity in her career, but will also allow her to develop a spectrum of new and interdisciplinary skills, integrating her previous training and knowledge into the behavioural genetics skills set. This project will also allow Dr. Brennan's group to integrate developmental toxicology into existing behavioural research, and will generate new collaborations.
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Group: Projects completed before 1 January 2021
Coordinator: QUEEN MARY UNIVERSITY OF LONDON
Country: United Kingdom
Description: 'The importance of natural products and derivatives as sources of new drugs is undeniable. Newman has stated:
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Biobutanol is an attractive commodity chemical and advanced biofuel with superior properties but the 1st gen process suffers from technical and economical constraints. ButaNexT project aims to overcome some of those technical barriers through a novel combination of innovations. Individual stages of the process supply chain will be developed, validated and optimized at lab-scale and then integrated and demonstrated at pilot scale. A holistic approach is proposed to produce cost-competitive biobutanol from 3 types of lignocellulosic biomass and waste in a sustainable way being flexible to accommodate regionally specific feedstocks.
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Coordinator: Green Biologics Ltd.
Country: United Kingdom
Description: Electricity Distribution Services Ltd (EDS) is a global leader in High Voltage (HV) asset management for offshore wind farms. In the offshore wind industry, newly commissioned engineering projects often experience failures either in the initial years of operation or at the end of their lifecycle. Subsea cable damage most often arises from: anchor strikes, dragging fishing nets and erosion. Statistics show that a wind farm cable circuit of average length is likely to experience 1-2 faults per 20-year period. Insurance companies increasingly report on HV cable faults being a major issue for financial losses at offshore wind farms. They led to insurance claims totaling more than €60 million in 2015. On average, at least 10 subsea cable failures are declared to insurers each year in the offshore wind sector. The financial severity of these incidents continues to grow – such that they account for 77% of the total global cost of offshore wind farm losses. Our CableSENTRY is an innovative solution based on Digital Acoustic Sensing (DAS) technology that detects subsea cable faults in real time. Acoustic signals from the HV cable create an optical response in a fibre optic line so faults and other events can be located accurately and immediately on a calibrated system. Applied in addition to existing fault location technology, our solution will be able to identify fault locations in land and subsea HV cables and save an average of 4 days’ downtime per fault over current methods
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Coordinator: ELECTRICITY DISTRIBUTION SERVICES LIMITED
Country: United Kingdom
Description: Cambrian Intelligence (“Cambrian”) is a novel retrofittable Artificial Intelligence (AI) software. The solution makes robots adaptive and cuts down robot configuration times from 2-3 weeks to a single day. As a result, production flexibility increases and costs are cut by a factor of \10x.
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Coordinator: CAMBRIAN INTELLIGENCE LTD
Country: United Kingdom
Description: The formation of crystalline solids from liquid-phase precursor is a central idea in materials chemistry. Organic crystal structures can be found in a large number of products, including food, explosives, pigments and pharmaceuticals. Control of molecular assembly is therefore a fundamental problem for both research and industry and it involves substantial scientific and economic challenges. For example, polymorphism is crucial for drug manufacturers because the crystal structure, morphology and size, can all affect the stability, efficacy and production cost of the drug. Therefore, it is essential to achieve a deep understanding on the molecular processes happening at the early stage of crystallization. Although important results have been obtained, our understanding on how a crystal of organic molecules nucleates on a surface is still poor. To go beyond state-of-the art we need techniques able to probe rare nucleation events with nanoscale resolution and very high sensitivity, providing direct insights on the structure of the nuclei and their interaction with the environment.
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Coordinator: THE UNIVERSITY OF MANCHESTER
Country: United Kingdom
Description: This project aims to advance our understanding of the forces that have driven the proliferation of risk discourses in the UK and Germany since World War Two. Working at the boundaries of risk sociology and corpus linguistics, this is a highly innovative enterprise, both theoretically and methodologically. It will examine the contribution made by main-stream risk theories to explaining the increasing use of the risk semantic in media coverage during the last 50 years, and it will develop an empirically grounded theory of the observable shift towards risk. The Fellow will utilise cutting-edge corpus-based research strategies to systematically reconstruct the changing use of the discourse-semantics of risk and will complement these with interviews of media experts to examine how these changes are linked to institutional and socio-cultural changes and historically significant events.
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Coordinator: UNIVERSITY OF LANCASTER
Country: United Kingdom
Description: BIRTHBRAZIL is an interdisciplinary project that will analyze how enslaved women’s reproductive trends and practices shaped the gradual abolition of slavery in the middle to large plantation holdings of Rio de Janeiro, Brazil from 1850 (the definitive end of the country’s slave trade) to final abolition in 1888. The project aims to contend that the struggle to end slavery was intimately entangled not only with elite understandings of slave reproduction but also with enslaved women’s own agency. To do so, it examines demographic trends among the enslaved population, elite views of enslaved women’s reproduction, and enslaved women’s own reproductive practices and agency. Like most Atlantic slave societies, the Brazilian slave population was reproduced through imports and not natural growth. Historians have argued that for 19th-century Rio de Janeiro state, harsh labour regimes and disease caused negative growth rates, dismissing the idea of “reproductive resistance”—the female enslaved practices of abortion and infanticide as purposeful attacks on the institution of slavery—popular in theories on Caribbean and US slavery. While enslaved women’s fertility control may not have caused negative population growth in 19th-century Rio de Janeiro state, BIRTHBRAZIL hypothesizes that enslaved women’s practices of fertility control played an important symbolic role in how elites understood and approached slavery itself. The findings of BIRTHBRAZIL are expected to demonstrate that enslaved women’s fertility control, both real and imagined, created the opportunity for abolitionists to implement the legal framework that abolished slavery. In doing so, the project provides historical background to current-day debates on reproductive rights, women’s health, and gender equality. The results will be disseminated through an academic monograph, peer-reviewed open-access publications, a website, an international conference, public history blogs, and a series of community lectures.
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Coordinator: THE UNIVERSITY OF EDINBURGH
Country: United Kingdom
Description: 'The use of infant-directed media has increased substantially, from 17% in the 1990s to now over 50% in the first year of life although this use is highly controversial. Current motion picture rating systems in Europe only target viewers above 3 years, and only in terms of content. Infant-directed videos include a wide range of cinematic techniques which require film literacy to understand. It is therefore crucial to investigate comprehensively the role of such techniques on infant attention so as to ascertain the impact videos may have on the developing brain. The overall objective of the proposed research is to assess systematically the role of: (a) cinematic techniques, (b) viewing experience and (c) cognitive development on the comprehension of moving images and, on the basis of the findings, (d) to suggest an 'age-appropriateness' rating scheme for infants and toddlers (e.g. 12m\, 24m\) for audiovisual material. Six-, 12-, 18-, 24- and 36-month-old young children will be categorized into two groups according to the extent of their viewing experience and tested in a cross-sectional study, the findings of which will have important implications for children’s mental development by identifying the age-appropriate cinematic techniques for comprehension of moving images, which may be suitable educational media for infants. This proposal falls squarely within the topics emphasized in the EU 7th Framework socio-economic sciences and humanities themes; it is multidisciplinary, combining film studies, vision sciences, cognitive psychology, developmental psychology, and developmental neuroscience, and will yield significant contributions to the film, TV and educational technology fields within the European Research Area.'
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Coordinator: BIRKBECK COLLEGE - UNIVERSITY OF LONDON
Country: United Kingdom
Description: This year, over 5 million European infants will be born into an intellectually demanding and technologically sophisticated world. These children's success in learning academic, linguistic, and social skills will play a large part in determining their future health, wealth, and happiness - and in driving European social and economic success. Thanks to new technologies, we have an unprecedented opportunity to individually tailor the learning process on a massive scale. The importance of a personalised learning approach is highlighted by recent research showing that individual children's and ultimately adults' abilities across various domains are strongly influenced by neural, genetic, environmental, educational, cognitive, and socioemotional drivers that interact over development. However, we have a very limited understanding of how, when, and why these factors might affect any given child's learning trajectory - and above all, how that child will respond to an intervention or novel challenge to learning. The INTERLEARN European Industrial Doctorate programme will train a cohort of five early stage researchers who can lead a new European-wide initiative to deliver technologically advanced and scientifically rigorous individualised learning paradigms. Each of the interlocking research projects in INTERLEARN takes a theoretically and neuroscientifically grounded, developmental, and multimethodological approach to uncover how and when to manipulate a child's learning environment to maximise her or his potential, and to design and implement tools to deliver these learning manipulations.
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Coordinator: BIRKBECK COLLEGE - UNIVERSITY OF LONDON
Country: United Kingdom
Description: A major problem with current chemical processing tools is that they use rollers to transport and support foil (any thin roll-to-roll substrate) through chemical treatment chambers located between un-winding and re-winding mechanisms. Roller transport limits and potentially prohibits fine detail treatment and reduces yield (to 10% in extreme cases) due to damage caused by contact with such rollers. Current technology employs long process tanks and slow speeds to minimise contact damage. In applications where contact is of less concern rollers still limit capability as the force required to turn them results stretching or breaking of the foil limiting foil type, thickness, and process residence times.
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Coordinator: CIRCUIT ENGINEERING MARKETING COMPANY LIMITED
Country: United Kingdom
Description: Organic/low input cereal food systems in the EU are emerging in answer to the sustainability crisis of the conventional agri-food sector. “Alternative” systems are based on local, decentralized approaches to production and processing, regard to quality and health, and short supply chains for products with strong local identities. Diversity is deeply embedded in these food systems, from the agro-biodiversity grown in farmers’ fields, which improves resilience and adaptation, to diverse approaches, contexts and actors in food manufacturing and marketing. Diversity thus becomes a cross-sectoral issue, underlying innovations in the agronomic, processing, and marketing phases which respond to consumers’ demand for healthy products. CERERE’s objective is to foster and speed up these innovations to strengthen the economic, social and environmental sustainability of these cereal food systems, consolidate links among practitioners and with researchers, further enhance the resilience of agro-ecosystems and make the overall sector more competitive and better recognized by society. By creating a multi-actor network of researchers and communities of practice, by adopting a bottom-up approach, and by liaising with EIP-AGRI Operational Groups, CERERE will synthesize, share and disseminate existing best practices, research results and co-innovative solutions in organic/low-input cereal food systems, focusing particularly on agro-biodiversity and the associated values of quality and health. Through its activities and training products, CERERE will address the key issues and most urgent needs of these systems: availability/ management of adapted germplasm, use of rotations, soil fertility, weed competitiveness and crop protection strategies, quality-oriented processing techniques, alternative marketing schemes. For each of these, CERERE will identify opportunities for better integrating science and practice, paving the way for more dynamic interactions between the two domains.
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Coordinator: THE UNIVERSITY OF READING
Country: United Kingdom
Description: We look for new physics in events with top quarks using LHC proton-proton collisions at the CMS detector. A direct search for top quark partners in the form of vector-like quarks is performed, complemented by an indirect but model-independent search for new physics interacting with top quarks using precision top quark properties measurements. In order to enable these and similar analyses to continue at the future High Luminosity LHC, we study the performance of the upgraded track trigger for events with top quarks, including optimisation of reconstruction algorithms and working points.
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Coordinator: SCIENCE AND TECHNOLOGY FACILITIES COUNCIL
Country: United Kingdom
Description: Nitroaromatics are a vast group of molecules of interest in different fields of research and applications: for example urban atmospheric contamination, energy materials and to the drug delivery sector. The simplest nitroaromatics compounds are nitrobenzene, 1-nitronaphthalene, and 2-nitronaphthalene. The study of such systems will then constitute the most natural starting point in order to investigate the properties of the nitroaromatics group of compounds. Moreover these three particular molecules are characterized by important and in some case unique photophysical and photochemical properties. For example, 1NN is the organic compound with the fastest multiplicity change ever measured. Recently, an increasing interest in NB has occurred in relation to the so-called roaming radical reactions, which are a new type of reactions that follow a mechanism not contemplated in transition-state theory. With the present project, we aim to characterize the photophysics and photochemistry of the related systems NB, 1NN and 2NN under UVA/UVB exposure through the computation of ab initio quantum chemical dynamics simulations. In particular we will study: their main decay paths, the intersystem-crossing process toward the triplet manifold, the mechanisms leading to the photoisomerization of the nitro into a nitrite group, including the possibility of roaming radical photoisomerization, and the competition among all the mentioned processes.
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Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: Today, the twinned ideas of respect towards minorities’ rights and cultural diversity that have been projected as values derived from the European historical experience are facing well-documented challenges. These include: the current radicalisation of young people in Europe; processes questioning the meaningfulness of the European project; and the revival of tribal identities and separatism. These processes give cause to fundamentally rethink the idea of Europeanness as a culture of dialogue and mutual respect. CHIEF aims to build an effective dialogue between different stakeholders in order to facilitate a future of Europe based on more inclusive notions of cultural heritage and identity. The project is innovative in its approach to cultural literacy of young Europeans by privileging the importance of production and transition of cultural knowledge in both formal educational settings initiated from above, and a variety of informal human interactions. These informal interactions are often overlooked despite their strong influence on how knowledge about European culture is acquired by young people. The project proposes to explore them by building an inter-disciplinary, multi-sectoral and transnational partnership in nine countries in and outside the EU. Through its research activities and social interventions, CHIEF will have a substantial impact on policies and practices facilitating intercultural dialogue in Europe. It will contribute to understanding and enhancing cultural literacy for young people, resulting in greater appreciation of diversity. The project will lead to more effective use of European cultural heritage as a site of production, translation and exchange of heterogeneous cultural knowledge. Moreover, it will help to recognize existing innovative practices and develop a new organisational model to enhance cultural and inter-cultural competence of young Europeans. Finally, it will empower and bolster the innovative capacities of its beneficiaries.
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Coordinator: ASTON UNIVERSITY
Country: United Kingdom
Description: The NeuPheMi project presents a novel approach in the neuroscientific study of mental imagery. Mechanisms of mental imagery are not yet well understood and while traditional approaches investigated their neural correlates based mostly on problem-solving tasks, NeuPheMi proposes to shed the light on the neural correlates of experiencing mental imagery. By taking into account the subjective experience and using electroencephalography and brain stimulation techniques to investigate the dynamic of neuronal activity during mental imagery in an original neurophenomenological approach, NeuPheMi is expected to bring a better understanding of the neuronal basis of mental imagery and extend our comprehension of human consciousness.
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Coordinator: UNIVERSITY OF PLYMOUTH
Country: United Kingdom
Description: Europe needs to import a half of the gas consumed, with the associated economic and geopolitical costs that it means. In the last years non-conventional gas sources have been developed. It is necessary to bet for new sources which are sustainable, as those based in biomass. The announcement made by the G7 Group at the Summit of June 2015 of phasing out fossil fuels by the end of the century is aligned with the European frameworks for 2020, 2030 and 2050.
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Coordinator: OSPRE LIMITED
Country: United Kingdom
Description: A highly significant division in present-day Europe is between two types of legal system: the Continental with foundations in Civil Law (law with an ultimately Roman law basis), and English Common Law. Both trace their continuous history back to the twelfth century. The present project re-evaluates this vital period in legal history, by comparing not just English Common Law and Continental Civil Law (or “Ius commune”), but also the customary laws crucially important in Continental Europe even beyond the twelfth century. Such laws shared many features with English law, and the comparison thus disrupts the simplistic English:Continental distinction. The project first analyses the form, functioning and development of local, national, and supra-national laws. Similarities, differences, and influences will then be examined from perspectives of longer-term European legal development. Proper historical re-examination of the subject is very timely because of current invocation of supposed legal histories, be it Eurosceptic celebration of English Common Law or rhetorical use of Ius commune as precedent for a common European Law.
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CountryCode: UK
Coordinator: THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
Country: United Kingdom
Description: The classification of Fano manifolds is a long-standing and important open problem. Fano manifolds are basic building blocks in geometry: they are `atomic pieces' of mathematical shapes. We will take a radically new approach to Fano classification, combining Mirror Symmetry (a circle of ideas which originated in string theory) with new methods in geometry and massively-parallel computational algebra.
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Coordinator: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Country: United Kingdom
Description: COGNITUS will deliver innovative ultra-high definition (UHD) broadcasting technologies that allow the joint creation of UHD media exploiting the knowledge of professional producers, the ubiquity of user generated content (UGC), and the power of interactive networked social creativity in a synergistic multimedia production approach.
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Coordinator: BRITISH BROADCASTING CORPORATION
Country: United Kingdom
Description: Active liquid crystals are out-of-equilibrium systems that display intriguing dynamic phenomena, arising from the interplay This multidisciplinary research programme is focussed on the optical manipulation of interfaces, droplets and crystallites in colloidal model systems. In particular, we will use holographic optical tweezing and confocal microscopy to study interfacial phenomena in three different phase separated colloid-polymer mixtures, exhibiting colloidal liquid-gas, crystal-gas and nematic-isotropic phase coexistence, respectively. First, we will determine the full potential energy landscape of the optical traps using the relation between interface fluctuations and deformed liquid-gas interfaces. This will then be used to study the complex and anisotropic interfacial properties of crystal-gas and nematic-isotropic interfaces. In addition, we envisage quantitatively investigating the nucleation of colloidal liquid droplets, crystallites and liquid crystalline droplets in optical traps positioned at well-defined heights above the interface, which is a direct and quantitative measure for the undersaturation. This allows us to systematically study the relation between the quench depth, nucleus size and nucleation times. We will furthermore nucleate multiple droplets, crystallites and liquid crystalline droplets to study their optical trapping controlled coalescence and detachment, which will shed completely new light on for instance the single particle structure and dynamics upon coalescence and detachment. Finally, we will introduce large probe particles into the phase separated colloid-polymer mixtures, which enables the study of important phenomena such as heterogeneous nucleation and capillary condensation, crystallisation and nematisation. This ambitious project opens up a huge range of exciting possibilities to gain a deep and fundamental understanding of interfacial phenomena in complex fluids by actively manipulating and controlling colloidal interfaces, droplets and crystallites.
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CountryCode: UK
Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD, THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Active liquid crystals are out-of-equilibrium systems that display intriguing dynamic phenomena, arising from the interplay This multidisciplinary research programme is focussed on the optical manipulation of interfaces, droplets and crystallites in colloidal model systems. In particular, we will use holographic optical tweezing and confocal microscopy to study interfacial phenomena in three different phase separated colloid-polymer mixtures, exhibiting colloidal liquid-gas, crystal-gas and nematic-isotropic phase coexistence, respectively. First, we will determine the full potential energy landscape of the optical traps using the relation between interface fluctuations and deformed liquid-gas interfaces. This will then be used to study the complex and anisotropic interfacial properties of crystal-gas and nematic-isotropic interfaces. In addition, we envisage quantitatively investigating the nucleation of colloidal liquid droplets, crystallites and liquid crystalline droplets in optical traps positioned at well-defined heights above the interface, which is a direct and quantitative measure for the undersaturation. This allows us to systematically study the relation between the quench depth, nucleus size and nucleation times. We will furthermore nucleate multiple droplets, crystallites and liquid crystalline droplets to study their optical trapping controlled coalescence and detachment, which will shed completely new light on for instance the single particle structure and dynamics upon coalescence and detachment. Finally, we will introduce large probe particles into the phase separated colloid-polymer mixtures, which enables the study of important phenomena such as heterogeneous nucleation and capillary condensation, crystallisation and nematisation. This ambitious project opens up a huge range of exciting possibilities to gain a deep and fundamental understanding of interfacial phenomena in complex fluids by actively manipulating and controlling colloidal interfaces, droplets and crystallites.
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CountryCode: UK
Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD, THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Lysine acetylation is a key protein post-translational modification (PTM) found throughout the cellular environment and across the range of species. This PTM is dynamic, with histone acetyl transferases (HATs) acetylating lysine, and histone deacetlyases (HDACs) reversing the modification. In addition, proteins modules bromodomains, have been identified that bind to acetylated lysine (KAc) and mediate protein-protein interactions. In humans, bromodomains exist as part of larger proteins, many of which are involved in transcriptional regulation. Bromodomains contain a KAc-binding pocket for which small molecule ligands have been identified. These ligands prevent the interaction of bromodomains with KAc and have been invaluable in dissecting the fundamental biology mediated by bromodomain-containing proteins (BCPs). We and others have developed potent ligands for the human bromodomain and extra C-terminal domain (BET) bromodomains. These compounds have antiproliferative effects in cancer cells lines and modulate inflammation and atherosclerosis. This work led to an explosion of interest in developing BET bromodomain inhibitors, resulting in 5 compounds in clinical trials. Despite rapid progress in understanding the role of human bromodomains, their function in other species is poorly understood. Given the fundamental role played by bromodomains in humans, we hypothesise that BCPs will play equally important roles in other organisms.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: This project provides the first comparative historical analysis – local, national and transnational - of the Central African copperbelt. This globally strategic mineral region is central to the history of two nation-states (Zambia and Democratic Republic of Congo (DRC)), as well as wider debates about the role of mineral wealth in development. The project has three interrelated and comparative objectives. First, it will examine the copperbelt as a single region divided by a (post-)colonial border, across which flowed minerals, peoples, and ideas about the relationship between them. Political economy created the circumstances in which distinct political cultures of mining communities developed, but this also involved a process of imagination, drawing on ‘modern’ notions such as national development, but also morally framed ideas about the societies and land from which minerals are extracted. The project will explain the relationship between minerals and African polities, economies, societies and ideas. Second, it will analyse how ‘top-down’ knowledge production processes of Anglo-American and Belgian academies shaped understanding of these societies. Explaining how social scientists imagined and constructed copperbelt society will enable a new understanding of the relationship between mining societies and academic knowledge production. Third, it will explore the interaction between these intellectual constructions and the copperbelt’s political culture, exploring the interchange between academic and popular perceptions. This project will investigate the hypothesis that the resultant understanding of this region is the result of a long unequal interaction of definition and determination between western observers and African participants that has only a partial relationship to the reality of mineral extraction, filtered as it has been through successive sedimentations of imagining and representation laid down over nearly a century of urban life in central Africa.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Each year 15 million babies are born prematurely and many suffer from respiratory failure due to immaturity of the lung and lack of control of breathing. Although respiratory support, especially mechanical ventilation, can improve their survival, it also causes severe injury to the vulnerable lung resulting in severe and chronic pulmonary morbidity lasting in to adulthood. Heterogeneity of lung aeration, resulting in areas of lung over inflation and lung collapse, plays a crucial part in the risk of mortality and morbidity due to respiratory failure. This distribution of lung aeration cannot be detected by currently available bedside monitoring tools and imaging methods. Thus, an imaging technique for continuous non-invasive bedside monitoring of infants lung function is urgently needed. In order to address this, CRADL will use EIT technology to establish a monitoring tool for interventions in the paediatric population.
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Coordinator: MIDDLESEX UNIVERSITY HIGHER EDUCATION CORPORATION
Country: United Kingdom
Description: CRESTING will train Early Stage Researchers (ESR) in cutting edge systematic analysis of the process of transformation to a Circular Economy (CE). Establishing a CE (such that the maximum value is extracted from materials and waste generation minimised) is a major policy area within the European Union and elsewhere. Explicitly seen as increasing economic competitiveness and laying a foundation for environmental employment, CE policies are designed to increase resource efficiency and decrease carbon dependency. Previous and ongoing research into the CE, however, has been largely concerned with strategies for implementation. The many different fields of activity comprising the CE (e.g., re-use, recovery, recycling, eco-design amongst others) operate with varying degrees of effectiveness in different places and for different materials. These fields of activity have not been critically analysed as an interrelated social, technical, environmental and, significantly, spatial phenomenon. This programme will advance the critical analysis of the concept and sustainability implications of the CE by the training of 15 ESR analysing CE-related activity and initiatives in a range of geographic and economic settings. CRESTING is divided between 5 work packages (WP) analysing: current discourse and policy contexts (WP1); corporate engagement with the CE (WP2); public sector engagement in the CE (WP3); the potential for local economic development and employment from the CE (WP4); and measuring life cycle impacts and developing sustainability indicators relevant to the CE (WP5). With multidisciplinary and international supervisory teams including non-academic partners within each WP, CRESTING will 1) analyse the sustainability implications of the CE; 2) analyse the spatial dimension of the CE and 3) translate these analyses into specific actions for managing the transformation to the CE.
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Coordinator: UNIVERSITY OF HULL
Country: United Kingdom
Description: The objective of my project is to develop new methods to transform environmentally persistent hydrofluorocarbons (HFCs) and hydrofluoroolefins (HFOs), into reactive chemical building blocks that can be used in chemical manufacture. My team will achieve this by developing a series of new chemical reactions that transform inert carbon–fluorine bonds in HFCs or HFOs into reactive carbon–boron or carbon–aluminum bonds. My team will show that these reactive species can be used to construct carbon–carbon bonds. The idea is to develop a net series of reactions that results in the fixation of fluorine from low-value, volatile, and environmentally damaging organic molecules to high-value, non-volatile organic molecules. When successful, this approach should open up new routes that allow the chemical industry to repurpose HFCs and HFOs as chemical intermediates, and not end products, that complements European Union legislation. By the end of this project, my team will have pioneered methods for the production of agrochemicals and pharmaceuticals from environmentally persistent fluorocarbons.
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Coordinator: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Country: United Kingdom
Description: The aim of the fellowship is to pioneer a synthetic method to form carbon–carbon bonds from the coupling of two carbon–fluorine bonds. This method will result in new routes to fluorinated biaryls, organic molecules that are used in materials science or as the active ingredient in pharmaceuticals and agrochemicals. It will open up new pathways to using inexpensive and environmentally persistent fluorocarbons in synthesis.
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Group: Projects completed before 1 January 2021
Coordinator: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Country: United Kingdom
Description: Understanding spoken language involves a complex set of processes that transform the auditory input into a meaningful interpretation. Our percept is not of acoustic-phonetic detail but of the speaker’s intended meaning. This effortless transition occurs on millisecond timescales, with remarkable speed and accuracy, and without any awareness of the complex computations on which it depends. How is this achieved? What are the processes and representations that support the transition from sound to meaning, and what are the neurobiological systems in which they are instantiated? In this proposal, we combine advanced techniques from neuroimaging, multivariate statistics and computational linguistics to probe directly the dynamic patterns of neural activity, over bilateral fronto-temporal and parietal cortices, that are elicited by spoken words and sentences. Combined MEG \ EEG imaging, linked to parallel fMRI studies, capture the real-time electrophysiological activity of the brain. Representational Similarity Analysis (RSA) and related multivariate techniques make it possible to probe the different types of neural computation that support these dynamic processes of incremental interpretation. Computational linguistic analyses of language corpora allow us to build quantifiable models of different dimensions of language interpretation – from phonetics and phonology to argument structure and anaphora - and to test for their presence, using RSA, as the utterance unfolds in real time. By this means we aim to determine directly the nature of the intermediate processes involved in the transition from early perceptual processing through different representational states to the development of a meaningful representation of an utterance, the dynamic spatio-temporal relationship between these processes, and their evolution over time.
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Coordinator: THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country: United Kingdom
Description: Dashboard is an early stage technology company formed to develop and market an automated remote monitoring solution for the collection and consolidation of near-real-time data from sensors in both remote and accessible locations. As a cleantech company Dashboard is rooted in the transformational power of data analytics, and through the knowledge and skills of our experienced team of hardware, programming and communications professionals, has developed Limpet, an alternative solution to monitoring pipelines for leaks and breaches.
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Coordinator: DASHBOARD LIMITED
Country: United Kingdom
Description: Large quantities of 16th-Century Italian ‘popular’ books – the books read or ‘listened to’ by everyone during the Early Modern Period, printed with poor quality material and having usually a short life expectancy –, sometime after the 16th century found their way to the UK to join the largest single collection of Italian 16th-century books in the world, that is the British Library (BL). This library preserves today a substantial number of early Italian editions which do not survive in any Italian library and are still not adequately recorded.
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Coordinator: Consortium of European Research Libraries
Country: United Kingdom
Description: One of the main functions of the visual system is to help the animal navigate through its environment, and one of the main ways that animals navigate is by using visual landmarks. Visually-guided navigation requires a change of coordinates from an eye-centered to a world-centered representation of the external environment. We know much about the two ends of this transformation, i.e. about the visual selectivity of neurons in Primary visual cortex and the place selectivity of place cells in hippocampus CA1. However, little is known about how this transition happens along the way. The recent development of virtual reality environment might help filling this gap: mice can navigate through an artificial environment while their head is fixed, therefore enabling a careful monitoring of the animal behavior, accurate control of the displayed visual inputs and the stability of the recording. In this project, we propose to investigate the transition from an eye-centered to a world-centered representation across the successive visual areas of the mouse cortex. Using a combination of electrophysiological and imaging techniques, we will record simultaneously in hippocampus CA1 and in different visual cortical areas while head-fixed mice navigate through a virtual maze to get a reward at specific locations. We will also take advantage of the virtual reality setup to modify visual cues and navigational cues such as to estimate the nature of the modulation of visually driven responses by navigational information. This approach will help understand how visual processing in cortical areas is modulated by the animal’s position in the environment. We believe that it will also set the foundations for a new field of research that investigates the function of the visual cortex as part of the navigation system rather than a simple feature analyzer of the visual scene.
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Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: More and more, organizations are generating huge amounts of data, which need to be stored and processed in order to gain useful insights and achieve competitive advantage. While the storage and analysis are nowadays mostly carried out by computers, the interpretation of data is still performed by humans through visual means.
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Coordinator: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Country: United Kingdom
Description: Inorganic polymers are of widespread interest as a result of their useful combination of physical and chemical properties, which offer exciting opportunities for their use as advanced materials for many different applications. In the proposed research state-of-the-art strategies worked out in organic catalysis will be applied for the first time to main group substrates to form main group element-element (specifically Si–O and PV–O) bonds, targeting efficient new routes to inorganic polymers that involve mild reaction conditions and permit microstructure control. Once formed, the new polymeric materials will be characterized in detail and potential applications explored. To achieve these objectives Dr. Lipeng Wu, an exceptionally talented young scientist from China who performed his Ph.D. and postdoc in top organic catalysis groups in Germany (Matthias Beller, Rostock) and the USA (F. Dean Toste, UC Berkeley), will work in the internationally leading research group of Prof. Ian Manners (Bristol, UK) with expertise in catalysis with main group substrates, inorganic polymers, and polymer materials science. Armed with the new knowledge and experience gained, following the fellowship Dr. Wu aims to obtain an academic position in China where catalysis with main group compounds and inorganic polymers play a key role.
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Coordinator: UNIVERSITY OF BRISTOL
Country: United Kingdom
Description: DEEP TIME will unearth a record of geological time that is buried thousands of kilometres deep. The seafloor that covers two-thirds of the earth's surface is a tiny fraction of all seafloor created during its history – the rest has sunk back into the viscous mantle. Slabs of subducted seafloor carry a record of surface history: how continents and oceans were configured over time and where their tectonic plate boundaries lay. DEEP TIME will follow former surface oceans as far back in time as the convecting mantle system will permit, by imaging subducted slabs down to the core with cutting-edge seismological techniques. Current tectonic plate reconstructions incorporate little if any of this deep structural information, which probably reaches back 300\ million years; they are based on present-day seafloor, which constrains only the past 100-150 million years.
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CountryCode: UK
Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: This project aims to help people with dementia engage in social contexts to improve psychosocial wellbeing. People who are affected by Alzheimer’s disease or other dementias often face cognitive, behavioural and psychosocial difficulties, including impairment and degeneration of memory and of perceptions of identity. In a social context, this can cause difficulties of recognizing, relating to and empathising with other people. These difficulties often pose a challenge for engaging socially, reinforcing their effects and reducing personal well-being.
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Group: Projects completed before 1 January 2021
Coordinator: UNIVERSITY OF WOLVERHAMPTON
Country: United Kingdom
Description: Future treatments of cardiovascular conditions will benefit from our ability to harness progenitor cells or stem cells for therapeutic purpose. To achieve this promising goal the objective of this Marie-SkŁodowska-Curie Action is to dissect the molecular mechanisms that govern fundamental cellular differentiation processes in their normal physiological setting, the developing embryo. One such fundamental process is the control of cell lineage determination. This is important during both stem cell differentiation and embryo development, including heart development. In the heart, many of the diffusible signalling molecules, transcription factors and more recently non-coding RNAs and epigenetic factors that contribute to this process have been identified. This has facilitated rapid advances in our understanding of the molecular mechanisms underlying the control of cell fate choice, however many details remain to be elucidated. This Action will focus on enzyme complexes that remodel chromatin during the epigenetic changes that occur during heart development. These complexes, which consist of different BAF-subunits and a core enzyme called Brg1, determine whether or not chromatin is accessible to transcriptional regulators, and they form an important nexus governing lineage decisions. The Action will address an important gap in our understanding concerning the regulation of subunit composition of the complexes and how subunit composition affects their function. This project builds on recent pilot data and will use in vivo methods to investigate the regulation of chromatin remodelling factors by microRNAs during cardiac development in experimentally accessible chick embryos. Mechanistic gain- and loss-of-function experiments in embryos (WP1, WP2) will be complemented by genomic approaches (WP3) to determine the genome-wide dynamic coverage of BAF/Brg1 complexes during heart development.
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Coordinator: UNIVERSITY OF EAST ANGLIA
Country: United Kingdom
Description: The developing neocortex consists of two major neuronal subtypes–pyramidal neurons and interneurons. These two subtypes come together in the cortical plate, forming cortical circuits that can integrate and respond to external and internal stimuli. Despite recent advancement in the research on cortical networks of the developing brain, the mechanism involved in cortical circuit assembly remains relatively unexplored. This project aims to identify the sequence of events and factors involved in cortical circuit assembly in the developing mouse brain. As such, this project can be broadly divided into three main parts namely lamination, synaptogenesis and maturation of the MGE interneurons specifically. Currently, the exact mechanisms that govern MGE interneurons are still unknown except that it may involve cues that are produced by the pyramidal neurons. Therefore, we aim to use existing transcriptome data of the different neuronal layers coupled with the acquisition of the early- and late- born MGE interneurons transcriptome in order to identify the receptor-ligand pair that is involved in the specific lamination of MGE interneuron. We also aim to understand the sequence of events that occur during synaptogenesis and maturation of MGE interneurons. To achieve this, we will be performing live imaging on organotypic brain slices of sparsely labeled MGE interneurons and by selectively killing specific classes of interneurons in order to determine the effect of these cells on the maturation of the parvalbumin-expressing interneuron. Altogether, this proposed project will give a better insights into the factors and mechanisms underlying cortical circuit assembly in the developing brain and will pave the way for a better understanding into the aetiology of certain neurodevelopmental disorders.
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Coordinator: KING'S COLLEGE LONDON
Country: United Kingdom
Description: Cooling systems for Computing & Data Centres consume 30% to 40% of energy delivered into the centre spaces, while electricity use in CDCs represents 1.3% of the world total energy consumption. The traditional vapour compression cooling systems for CDCs are neither energy efficient nor environmentally friendly. Several alternative cooling systems, e.g., adsorption/absorption, ejector, and evaporative types, have certain level of energy saving potential but exhibit some inherent problems that have restricted their wide applications in CDCs. This RISE programme aims to form an international and inter-sectoral network of organisations working on a joint research and innovation programme dedicated to develop the design theory, computerised tool and technology prototypes for a novel CDC dew point cooling system. Such a system, comprising a few critical and highly innovative components (i.e., dew point air cooler, adsorbent sorption/regeneration cycle, micro-channels-loop-heat-pipe (MCLHP) based CDC heat recovery system, paraffin/expanded-graphite based heat storage/exchanger, and internet-based intelligent monitoring and control system), is expected to achieve 60% to 90% of electrical energy saving and have a comparable initial price to traditional CDC air conditioning systems, thus removing the above outstanding problems remaining with existing CDC cooling systems. Within the programme, the participants will exchange skills and knowledge that will allow them to progress towards the key target set for the CDC dew point cooling system, and strengthen collaborative research among different countries and sectors. The advances in the novel CDC dew point cooling system will have potential market opportunities for non-academic participants in the programme, and have significant benefits to European society and economy. The staff members who participate in the programme will develop new skills, be exposed to new research environments and have their career perspectives widened.
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Coordinator: UNIVERSITY OF HULL
Country: United Kingdom
Description: DigiArt seeks to provide a new, cost efficient solution to the capture, processing and display of cultural artefacts. It offers innovative 3D capture systems and methodologies, including aerial capture via drones, automatic registration and modelling techniques to speed up post-capture processing (which is a major bottleneck), semantic image analysis to extract features from digital 3D representations, a “story telling engine” offering a pathway to a deeper understanding of art, and also augmented/virtual reality technologies offering advanced abilities for viewing, or interacting with the 3D models.
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Coordinator: LIVERPOOL JOHN MOORES UNIVERSITY
Country: United Kingdom
Description: LEAPIN has developed a new type of access control and unlocking system. Digital Keys is a Software Development Kit that utilises apps and web-based software to set, send, receive and revoke time sensitive one-time use passwords (keys) to provide access anytime anywhere. A secure encrypted technology is used to overcome concern related to fear of hacking and security. The traditional magnetic stripe technology is outdated and the system is subject to regular failures. The installation of innovative smartlocks delivers a more reliable and secure system. LEAPIN’s patented technology allows Digital Keys users to open doors with their smartphones, to self check-in to accommodation/assets with their smartphones, to web check-in to their accommodation/assets, to continue to use keycards linked with Near Field Communications and enable complete self-management of accommodation without human interaction. Digital Keys require no supporting network infrastructure through the use of a one-time password cloud based software. The flexibility of remotely controlling and managing access to properties provides convenient accessibility and does not restrict operating hours. Within the overall project, LEAPIN aims to: implement Near Field Communication technology and Bluetooth Low Energy technology features into the LEAPIN Software Development Kit; undertake at least three pilot trials of the smart lock in hotels in 3 EU countries; undertake a market replicability test of the software platform and its functionality; and establish a sound marketing and commercialization strategy.
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Coordinator: LEAPIN DIGITAL KEYS LIMITED
Country: United Kingdom
Description: Over the past decade, worsening affordability,homelessness, social and housing polarisation and new forms of housing deprivation have been an increasing concern for public policy in Europe. Symptom of this problem is a set of art projects focused on housing issues. These social art projects have also served to highlight and fill the gap left by inexistent social structures, which should ideally provide wellbeing for all. The art projects about housing paired with other initiatives coming from civil society (as non-governmental organizations with social and humanitarian foundation, social entrepreneurship, and volunteer based social initiatives) have a potential to engage citizens creatively and initiate positive social change by increasing wellbeing and community feeling.
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Coordinator: LONDON SOUTH BANK UNIVERSITY LBG
Country: United Kingdom
Description: This grant will develop and translate a unifying framework for optimal decision-theory, and observations of natural systems, to design distributed algorithms for decentralised decision-making. This will enable a technological step-change in techniques for controlling distributed systems, primarily demonstrated during the grant by decentralised control of robot swarms. These algorithms and associated methodology will also provide hypotheses and tools to change the way scientists think about and interrogate natural decision mechanisms, from intracellular regulatory networks, via neural decision circuits, to decision-making populations of animals. Specific objectives are:
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Group: Projects completed before 1 January 2021
Coordinator: THE UNIVERSITY OF SHEFFIELD
Country: United Kingdom
Description: A new catalytic enantioselective cycloisomerisation reaction for the direct creation of the azabicyclic core of strychnos alkaloids is proposed. Strychnos alkaloids have been the subject of intensive investigation over the last decades. Recently, leuconicines A and B, which are new members of the Strychnos alkaloid family, have been isolated from extracts of the Malaysian plant Leuconotis maingayi. Leuconicines possess significant bioactivity and they potently reverse multidrug resistance in vincristine-resistant leukemia cells. However, further studies into the biological profile of these natural products are hindered due to insufficient quantities being available from the natural source. In order to secure sufficient quantities and fully determine the therapeutic potential of the leuconicines, a new source of these target molecules is required. A new synthetic route which develops and incorporates ‘state-of-the-art’ methodologies to rapidly forge the extremely complex 6,5,5,6,6,6 hexacyclic ring system and 4 stereocenters, will provide the material. Nevertheless, the synthetic routes toward complex natural products are usually long, contain many individual steps and involve manipulations after each step. For these reasons, new, simple and synthetically efficient organic transformations which reduce the drain of resources are desired. This Fellowship project combines total synthesis, new catalytic enantioselective methodology development, computational calculations and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: An increase in the age of onset of child-bearing increases in developed countries is leading to an increased incidence of chromosome abnormalities arising in defective meiosis. Accurate chromosome segregation requires a correctly assembled meiotic spindle and so it is essential to understand this process. Here we propose to examine how the spindle forms in the oocytes and early embryos of the mouse that, like human oocytes, lack centrioles. Nevertheless, spindle formation in these cells requires the function of Polo-like kinase 4, a protein that in somatic cells regulates centriole duplication. Plk4 localises to the acentriolar microtubule organising centres (MTOCs) where it particptates in regulating the nucleation of microtubules. We now wish to determine how Plk4 functions in these acentriolar cells to participate in spindle formation. This requires identifying the molecular partners of Plk4; the mechanisms that regulate its sub-cellular localisation to be in the vicinity of its substrates; and to identify its molecular substrates. We will also determine how it interacts with the Ran-GTP pathway, the other major pathway that regulates spindle formation in the absence of centrosomes. In the second part of the proposal we will address the behaviour of MTOCs in the oocyte and early embryo. There appear to be two distinct populations of MTOCs in the oocyte, one of which, the cytoplasmic MTOCs, appear to be essential for spindle bipolarity during metaphase by anchoring polar MTOCs. We wish to characterise these MTOCs to determine how they might differ from those at the spindle poles. The acentriolar MTOCs can also show differential behaviour at the spindle poles. This is most evident in the asymmetrical fate determining divisions at the 8-16 and 16-32 cell stage of the embryo. We wish to understand how this differential behaviour relates to cell polarity at these stages.
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Coordinator: THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country: United Kingdom
Description: 'Mineral weathering in the unsaturated zone from the molecular to macro scale (DryMIN)”
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Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: The European polymer industry is under increasing pressure to produce innovative products at lower cost to compete with overseas imports. Econic Technologies has invented a catalyst that enables replacing up to 40% of petrochemical feedstock in the production of polyurethane polyols, an important polymer segment, with low cost waste CO2, resulting in high performance product.
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Coordinator: ECONIC TECHNOLOGIES LTD
Country: United Kingdom
Description: Data explosion on the web, fuelled by social networking, micro-blogging, as well as crowdsourcing, has led to the Big Data phenomenon. This is characterized by increasing volumes of structured, semi-structured and unstructured data, originating from sources that generate them at an increasing rate. This wealth of data provides numerous new analytic and business intelligence opportunities to various industry sectors. Therefore, more and more industry sectors are in need of innovative data management services, creating a demand for Data Scientists possessing skills and detailed knowledge in this area. Ensuring the availability of such expertise will prove crucial if businesses are to reap the full benefits of these advanced data management technologies, and the know-how accumulated over the past years by researchers, technology enthusiasts and early adopters.
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Coordinator: THE OPEN UNIVERSITY
Country: United Kingdom
Description: In the wind power generation, aerospace and other industry sectors there is an emerging need to operate in the low temperature and highly erosive environments of extreme weather conditions. Such conditions mean current materials either have a very short operational lifetime or demand such significant maintenance as to render many applications either very expensive to operate or in some cases non-viable.
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Coordinator: TWI LIMITED
Country: United Kingdom
Description: Given the ageing population in Europe, it is critical to understand the mechanisms involved in growing old. Our ability to reduce the impact of ageing in humans might be best studied in equally long-lived animals. Predicting future changes in longevity patterns might depend on our ability to develop indicators of how old we really are and how many healthy years we have ahead of us, and how those indicators depend on our health history across decades.
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Coordinator: THE UNIVERSITY OF SHEFFIELD
Country: United Kingdom
Description: GeoRes aims to expand the scope of the involved teams’ research in addressing some of the outstanding challenges in geotechnical and geoenvironmental engineering: developing innovative solutions for the reuse of waste geomaterials generated by construction and mining industries across Europe. Geomaterial waste represents half of the waste volume generated in EU-27. These waste geomaterials generally exhibit poor engineering characteristics that prevent their direct reuse on construction/mining sites. However, if adequately treated, they could represent an excellent resource for construction purposes with significant money saving and reduction in the environmental footprint, thus contributing to the establishment of a circular economy. To achieve this, GeoRes will develop protocols, software and tools to improve the engineering characteristics of waste geomaterials, and to guarantee the level of performance over the service life of geostructures built from waste geomaterials considering site-specific conditions. The fundamental concern of the research in the GeoRes network is thus to develop strategies and tools for sustainable reuse of waste geomaterials generated by geoengineering activities, and to determine how to turn a waste geomaterial into a valued durable material, with a positive revenue stream. The proposed network is at the interface of two domains of engineering; geotechnical and geoenvironmental. Even today, it is not easy to find researchers with expertise in both geotechnical and geoenvironmental engineering. We intend to form a multidisciplinary and intersectoral consortium composed of 6 academic and 5 industrial beneficiaries and 6 Third Country partners which aim to address this problem. GeoRes will create a multidisciplinary and intersectoral network of creative and innovative researchers and practising engineers ready to face geotechnical and geoenvironmental engineering challenges which arise in the vanguard of technological innovation.
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Description: Lateral displacement of carbon (C) from soils across inland waters towards the ocean has been intensified due to anthropogenic perturbations and has significant influence on the anthropogenic C budget and the terrestrial C sink. However, Earth System Models (ESM) which are used to simulate the terrestrial C sink at global scale still ignore these lateral fluxes.
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Coordinator: THE UNIVERSITY OF EXETER
Country: United Kingdom
Description: One of the major driving forces for current research in electronics is the desire to realize the so-called internet of things, an autonomous information network that enables communication between objects without external human intervention. To this end, much of the research effort in device physics is currently directed into sensors technology, and specifically, to photodetectors. The infrared (IR) region of the spectrum is of particular interest as it can carry information about an object’s temperature, and its chemical composition. IR waves are also used for long-range waveguided communication, as well as short-range free space signaling. In IR systems, the readout noise is reduced by exploiting multicolor IR detection, so-called hyperspectral IR, thus lowering false positive detection.
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Coordinator: THE UNIVERSITY OF EXETER
Country: United Kingdom
Description: This project focuses on Sun-like stars, which possess convective envelopes and universally exhibit magnetic activity (in the mass range 0.1 to 1.3 MSun). The rotation of these stars influences their internal structure, energy and chemical transport, and magnetic field generation, as well as their external magnetic activity and environmental interactions. Due to the huge range of timescales, spatial scales, and physics involved, understanding how each of these processes relate to each other and to the long-term evolution remains an enormous challenge in astrophysics. To face this challenge, the AWESoMeStars project will develop a comprehensive, physical picture of the evolution of stellar rotation, magnetic activity, mass loss, and accretion.
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Coordinator: THE UNIVERSITY OF EXETER
Country: United Kingdom
Description: The ENCOMPASS project principally aims to create a fully digital integrated design decision support (IDDS) system to cover the whole manufacturing chain for a laser powder bed fusion (L-PBF) process encompassing all individual processes within in. The ENCOMPASS concept takes a comprehensive view of the L-PBF process chain through synergising and optimising the key stages. The integration at digital level enables numerous synergies between the steps in the process chain and in addition, the steps themselves are being optimised to improve the capability and efficiency of the overall manufacturing chain.
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Group: Projects completed before 1 January 2021
Coordinator: THE MANUFACTURING TECHNOLOGY CENTRE LIMITED
Country: United Kingdom
Description: Alkenones are algal lipids that have been used for decades to reconstruct quantitative past sea surface temperature. Although alkenones are being discovered in an increasing number of lake sites worldwide, only two terrestrial temperature records have been reconstructed so far. The development of this research field is limited by the lack of interdisciplinary research that combines modern biological and ecological algal research with the organic geochemical techniques needed to develop a quantitative biomarker (or molecular fossil) for past lake temperatures. More research is needed for alkenones to become a widely used tool for reconstructing past terrestrial temperature change. The early career Principal Investigator has discovered a new lake alkenone-producing species of haptophyte algae that produces alkenones in high abundances both in the environment and in laboratory cultures. This makes the new species an ideal organism for developing a culture-based temperature calibration and exploring other potential environmental controls. In this project, alkenone production will be manipulated, and monitored using state-of-the-art photobioreactors with real-time detectors for cell density, light, and temperature. The latest algal culture and isolation techniques that are used in microalgal biofuel development will be applied to developing the lake temperature proxy. The objectives will be achieved through the analysis of 90 new Canadian lakes to develop a core-top temperature calibration across a large latitudinal and temperature gradient (Δ latitude = 5°, Δ spring surface temperature = 9°C). The results will be used to assess how regional palaeo-temperature (Uk37), palaeo-moisture (δDwax) and palaeo-evaporation (δDalgal) respond during times of past global warmth (e.g., Medieval Warm Period, 900-1200 AD) to find an accurate analogue for assessing future drought risk in the interior of Canada.
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Coordinator: UNIVERSITY OF GLASGOW
Country: United Kingdom
Description: Planned Departure is an online business that addresses after-death and estate planning in the digital world, to offer a solution to this problem. It answers questions of transferring online assets by providing the tools to manage a digital life and making it easier to create a succession plan online. Planned Departure is a Software as a Service (SaaS) solution which is safe, reliable and cost effective, to allow storage of important information and after-death instructions, including defining specific beneficiaries to receive the information. Planned Departure seeks funding to conduct a feasibility study to prove technical and commercial viability, conducting an analytical exercise to position the product. The objective is to test the economic viability of the concept and platform among potential clients. By using research, experience and business principles, this feasibility study will determine the probability of the project to sustain itself and offer insight into future expansion prospects. The expected outcomes of the feasibility study are: to validate the business concept by demonstrating the need for a product like Planned Departure for the general public; engage with law firms to demonstrate reducing operating costs and increase profits by offering Planned Departure to their clients; engage with charities to gain interesting insight about their donors in order to raise more money by offering Planned Departure as a service; and prepare for European growth and international expansion.
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Coordinator: PLANNED DEPARTURE LIMITED
Country: United Kingdom
Description: Epilepsies are common and highly disabling diseases characterised by recurrent seizures. They constitute a relevant health problem: ~2 million adults suffer from active epilepsy in Europe, leading to significant direct and indirect costs (estimated to be ~14 billion euro (2010)). The scientific objective of this fellowship, to be carried out at the Division of Neuroscience at King's College London and the Centre of Predictive Modelling in Health Care of the University of Exeter, is to develop a novel type of diagnostic biomarker for idiopathic generalised epilepsies (IGE), an important group of syndromes that affects 25-30% of patients, particularly young adults. This will be achieved by conducting a cross-sectional case-control study that will use advanced quantitative neuroimaging techniques to measure alterations of brain network connections in IGE patients and healthy controls, and machine-learning algorithms to (1) classify patients with different seizure types according to these alterations, (2) predict their seizure risk, as assessed with long-term electroencephalography (EEG), and (3) model the effect of network disruption on brain dynamics, using computational modelling. The educational objective is to equip the fellow with the skills needed to become an independent clinical scientist in epileptology. This will be achieved through a comprehensive clinical and scientific teaching programme that will include: (1) part-time participation in clinical rounds and clinical long-term EEG monitoring of complex epilepsy, (2) training in the neuroanatomy and quantitative measurement of white matter connections of the human brain,(3) training in computational neuroscience, and (4) courses in scientific writing and project management. This programme is expected to broaden and diversify the fellow's skills, strengthen the ties between the cooperating research centers and yield novel insights that might help improve clinical management of a highly relevant disease group.
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Coordinator: KING'S COLLEGE LONDON
Country: United Kingdom
Description: There is a need to develop an autonomous, reliable, cost effective technology to map vast terrains, in terms of mineral and raw material contents which will aid in reducing the cost of mineral exploration, currently performed by ROVs and dedicated SSVs and crew. Furthermore there is a need to identify, in an efficient and non-intrusive manner (minimum impact to the environment), the most rich mineral sites. This technology will aid the seabed mining industry, reduce the cost of exploration and especially the detailed identification of the raw materials contained in a mining sites and enable targeted mining only of the richest resources existing.
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Description: This project will extend the successful standardization approach of the Investor Confidence Project beyond buildings and into Industry and Infrastructure. It will utilize a similar approach to the Horizon 2020 funded ICPEU project which developed standardization for building energy efficiency projects. It will develop standardized Protocols and associated tools (Project Development Specifications, Index of National Resources and Templates) for energy efficiency projects in industry and infrastructure - specifically street lighting and district energy. It will have a European wide communications plan, as well as work in five specific countries, building on the work of ICPEU. It will also develop and deploy trainings for Project Developers and Quality Assurance providers. Using the eco-system of Project Developers and its own networks the project will engage with project developers to certify projects and programmes as being Investor Ready Energy Efficiency (IREE). It will dedicate technical assistance resources to helping project owners and project developers to adopt IREE. It will also dedicate specific resources to working with financial institutions to help them incorporate IREE into their investment and lending procedures.
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Coordinator: ENERGYPRO LIMITED
Country: United Kingdom
Description: EuroPOND will develop a data-driven statistical and computational modeling framework for neurological disease progression. This will enable major advances in differential and personalized diagnosis, prognosis, monitoring, and treatment and care decisions, positioning Europe as world leaders in one of the biggest societal challenges of 21st century healthcare. The inherent complexity of neurological disease, the overlap of symptoms and pathologies, and the high comorbidity rate suggests a systems medicine approach, which matches the specific challenge of this call. We take a uniquely holistic approach that, in the spirit of systems medicine, integrates a variety of clinical and biomedical research data including risk factors, biomarkers, and interactions. Our consortium has a multidisciplinary balance of essential expertise in mathematical/statistical/computational modelling; clinical, biomedical and epidemiological expertise; and access to a diverse range of datasets for sporadic and well-phenotyped disease types.
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Group: Projects completed before 1 January 2021
Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: By the time of the Norman Conquest in 1066, England’s population was again comparable to that of Roman Britain and included substantial urban centres. By 1200, England was more densely populated than ever before. Such population growth was mirrored across much of Europe. It drove the expansion of towns and markets and was fed, literally, by an increase in agricultural productivity that involved a fundamental reorganization of the countryside. The social, economic and demographic consequences of this reorganization were so far-reaching that it has often been described as an ‘agricultural revolution’. At the heart of this proposal is the question, how and when was this revolution achieved? FeedSax will effect a breakthrough in understanding this critically important period in Europe’s agricultural history by generating new, direct evidence for changing land-use from the excavated remains of crops, animals and farms.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Monoma is a patent-pending cloud-based Software as a service (SaaS) solution integrating (i) modular, sensor based controllers (Hardware) and (ii) a platform with several therapy modules (Software), which (iii) collects and aggregates data insights to train people that have moderate-to-severe cases of Autism and other SEN. Monoma is designed to help users exercise regularly both cognitively and physically by triggering users’ creativity and engagement through games, music making and gamified training exercises. It is the only ergonomically accessible input device that is (i) fully customisable due to its bidirectional communication capacity, enabling new interaction possibilities and also adaptability to each end-user, (ii) that offers interoperability possibilities with other hardware and programmes enabling scalability and affordability, and (iii) collecting data insights to help therapists and educators assess the evolution of users’ capacities. The system has been developed by Filisia Interfaces, a UK-based company incorporated in 2014. Filisia’s customers are Therapist and Educators working in Special Schools, Therapy Centres and Care Homes. The company aims to penetrate its UK home market, scale up, and expand in Germany and the Netherlands, which together count for more than 649,342 educators and occupational, physical and music therapists who work in 160,000 institutions that cater for the needs of 3,441,400 people with SEN. Filisia aspires to become a key service provider, by making Monoma the main solution to cater for neuromuscular and cognitive impairments in the European and US markets, starting off with the UK, German and Dutch markets. By taking an average of only 2 solutions needed per centre, at its current pricing point (€450 for the device and €450 for the annual subscription), Monoma’s total addressable market for these 3 countries in 2016 is over €72M for the device, and €72M in recurrent annual subscriptions (a total of €144M).
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Coordinator: FILISIA INTERFACES LTD
Country: United Kingdom
Description: Filton Systems Engineering (FSE) intends to establish methodologies, which have been verified using test data, to provide validated accurate surge pressure predictions within aircraft fuel systems. This would replace physical Aerospace Test Rigs with a virtual test rig to reduce development cost and lead-time by improving the robustness/integrity of surge/ two phase flow fluid modelling. This allows aerospace companies to optimise architecture early in the design phase minimising installation and structural weight, increasing aircraft efficiency, thereby lowering operating cost and also reducing carbon footprint.
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Coordinator: FILTON SYSTEMS ENGINEERING LTD
Country: United Kingdom
Description: This European Training Network aims to produce the next generation of early stage researchers who will enable Europe to take a leading role in the development of future devices, systems and networks supporting the 5G high-speed wireless internet. To do this, researchers must be able to work in interdisciplinary teams, integrate their activities, share expertise, and promote a vision of a converged wireless and optical devices and networks that efficiently supports the services and applications being demanded. A large number of technologies and devices will need to converge, co-exist and interoperate, and most importantly, cooperate, if this vision is to be efficiently and cost-effectively realised. A key area within this next generation jigsaw is the integration of optical fibre networks and radio networks at mm-wave frequencies, to provide high-bandwidth front/backhaul services and enable scalable and manageable networks without a highly complex interface structure and multiple overlaid protocols.
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Coordinator: UNIVERSITY COLLEGE LONDON
Country: United Kingdom
Description: FLow of Ancient Metals across Eurasia (FLAME) is a new empirical and conceptual framework for understanding human interactions in Later Prehistory across all of Eurasia. Taking existing data on the chemical and isotopic composition of copper alloy objects and combining them with typological and chronological information within a GIS framework, FLAME aims to rewrite the history of human engagement with copper and its alloys across Eurasia, from Atlantic Iberia to the shores of the Pacific during approximately the 3rd to early 1st millennia BCE. It replaces the outdated concept of provenance with a completely new interpretative paradigm (‘form and flow’), which is built upon the expectation that copper may be recycled, re-alloyed and generally re-used, thus breaking the simple linear assumption of a direct chemical or isotopic link between the copper and the ore from which it came. In this new paradigm, small shifts in chemistry are interpreted not necessarily as changing ore sources but also as the natural consequence of high-temperature processing and mixing, thus putting the emphasis on human interaction with metal rather than on sourcing. We will address major questions at a range of scales, from assemblage to continental, to look at how metal flowed literally and metaphorically through the complex societies of Bronze Age Eurasia. Our reassessment of the metallurgy will also be underpinned by new GIS frameworks and the creation of regional Bayesian-modelled radiocarbon chronologies. Previous scientific assessments of early metal have too often isolated the chemical and isotopic evidence from both the immediate archaeological context and any sense of a real time and place. FLAME brings together a broad range of skills to examine for the first time the intertwined social, scientific, chronological and geographical aspects of Eurasian early metallurgy.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: The formation of carbon-carbon bonds in an asymmetric fashion is a very useful process in synthetic chemistry, since it generates single enantiomers of chiral molecules at the same time as the molecular framework is being assembled. In this context, two strategies for the generation of single enantiomer compounds using enantioselective catalysis have been widely emabraced: on the one hand, the use of prochiral substrates, and on the other hand, the use of racemic substrates in enantiomer resolution processes, which limits the yields up to 50%. An efficient variation of this second strategy is to couple enantiomer differentiation with interconversion of enantiomers. However, these dynamic kinetic asymmetric transformations (DYKAT) have been limited to the use of stabilized nucleophiles. Very recently, the group of Fletcher reported that alkylzirconium reagents can be employed as non-stabilized nucleophiles in combination with a copper-based catalytic system for this class of processes. Subsequently, the same group demonstrated that arylboronic acids are also suitable substrates in rhodium-catalyzed DYKATs. The project presented in this application aims to expand the scope of this powerful transformation by using vinyl- and heteroarylboronic acids as non-stabilized nucleophiles in the rhodium-catalyzed DYKAT. Moreover, a thorough study of the reaction mechanism will be conducted, as well as the investigation on alternative procedures for this process (catalytic systems, nature of the substrates, etc) that might result in useful applications for organic synthesis.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Flexion Mobile is a leading Android games monetisation service provider whose unique enabling products let developers and publishers monetise games outside Google Play. The Gamesmondo project, currently in TRL 6, is a major part of Flexion’s long-term strategy to become the first choice for Android game distribution outside Google Play, capture at least 100 million Monthly Active Users (MAU) with a target revenue of 25-35m EUR.
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Coordinator: FLEXION MOBILE PLC
Country: United Kingdom
Description: The flexolighting programme is focussed on research and innovations on materials, processes and device technology for OLED lighting with the intention of building a supply chain within Europe. The aim is to realise OLED devices over a large area/surface with high brightness, high uniformity and long life time. A demonstrator will be built and delivered at the end of the project. The main targets are (i). Cost of the lighting panels should be less than Euro 1 per 100 lumens. (II). high luminous efficiency, in excess of 100 lm/W with improved out-coupling efficiency. (ii). white light life-time of at least 1000 hours at 97% of the original luminance of 5000 cdm-2.(iii). The materials and the devices therefrom will allow for differential aging of the colours, thus maintaining the same colour co-ordinates and CRI over its use. (iv). Attention will be paid to recyclability and environmental impact of the materials and the OLED lighting systems. Flexolighting project will also ensure European industrial leadership in lighting.
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Coordinator: BRUNEL UNIVERSITY LONDON
Country: United Kingdom
Description: All of modern medicine is dependent on advances in chemistry and the healthcare goalposts have moved as the century has progressed. The pressing need to shorten cycle times and reduce the costs of drug discovery has led pharma and the clinicians that guide them to use scanning techniques such as positron emission tomography (PET), enabling them to increase disease understanding, study target engagement with therapeutics and improve decision making, so that only the best candidate molecules progress to the later stages of drug development. Overcoming these challenges requires multidisciplinary knowledge, and can be facilitated through stronger links between academia and Pharma. Chemical entities substituted with fluorine or fluorine-containing groups are frequently used to design drugs with improved pharmacological and pharmacokinetic profiles that provide important benefits over existing therapies, such as superior safety, efficacy, dosing, and patient compliance. Furthermore, 18F is often selected as the preferred positron-emitting isotope for the labeling of PET tracers due to its advantageous properties. The scientific objective of FLUDD is to develop novel late stage fluorination chemistry to populate the chemical and radiochemical space available for drug discovery with a focus on novel fluorine-containing fragments, molecules and biomolecules that are not directly accessible from commercial sources or the scientific literature. These novel methodologies will be applied to drugs and diagnostics discovery using both small molecules and proteins. The educational objective is to train the next generation of doctoral scientists in the practice of chemical synthesis and radiochemical methods with an in-depth appreciation of their applications in medicine. FLUDD objectives will be met with a novel Oxford-Janssen Alliance augmented with leading partners from academia, industry and the clinic.
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Coordinator: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country: United Kingdom
Description: Solid Oxide Cells (SOCs) should form an important part of any future energy mix, due to their flexible operation and
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Coordinator: THE UNIVERSITY OF SHEFFIELD
Country: United Kingdom
Description: AceForm4.0 will strengthen European leadership in the development and commercialisation of innovative and sustainable formulated products by i) engaging stakeholders and establishing a strategic common vision, European 2025 roadmap for formulated products and an associated implementation plan; and ii) facilitating knowledge exchange activities aiming at the formation of new collaborative value chains and partnerships in the context of the challenges, barriers and opportunities offered by Industry 4.0 and the drive towards a Circular Economy. Whilst a number of the challenges faced by manufacturers of formulated products are shared with the wider process industry, their nature is very different. Being often micro-heterogeneous, formulated products tend to be unstable and rely on a judicious selection of ingredients and fine-tuned production methods to guarantee physical and chemical stability during their lifetime. Compared to basic chemicals, this makes product development far more challenging in terms of, e.g.: 1) predicting the properties of combined ingredients at an early stage of their lifecycle for optimal use of ingredients; 2) designing new manufacturing processes and equipment; 3) selection of adequate modelling and simulation processes to minimise resources and energy utilisation; 4) scale-up from lab to production; and 5) developing in-stream high throughput metrology to enable quality control, plant automation and supply chain management. AceForm4.0 will establish and engage a European-wide Formulation Interest Group, comprising of stakeholders from industry, research institutes and government bodies to identify specific cross-sector challenges, barriers and opportunities. The resulting common European strategy will provide a framework for the rational development of sustainable products and stimulate targeted investment in RDI initiatives leading to new commercialised products, manufacturing facilities and services.
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Coordinator: CENTRE FOR PROCESS INNOVATION LIMITED LBG
Country: United Kingdom
Description: This project begins with the hypothesis that the origins of the French Wars of Religion (1562-98) must be traced to events in Scotland between 1557 and 1560 when Scottish Calvinists (Lords of the Congregation), with the support of their allies in England, overthrew the French Catholic regency of Mary of Guise. The multiple relations between England, Scotland and France were to have a major impact on events across Europe in the 1560s, profoundly altering the political and diplomatic balance of power in Europe. In particular, the Calvinist revolt in Scotland was to have a major impact in France. The ways in which events in Scotland inspired French Protestants to overthrow the existing political and religious order in the 1560s has been largely neglected by historians. This project therefore has a strong methodological and historiographical focus: the interactions and similarities between Scotland and France are such that it is necessary to go beyond traditional diplomatic and national histories. This project will seek to investigate and delineate the transnational aspects of the Calvinist revolt that bound English, Scottish and French religious and political events in the 1550s and 1560s into a connected history. It will also seek to demonstrate the impact of this connected history for the wider history of Europe. In particular, the formation of an embryonic Calvinist International in the 1560s, the shaping of Spanish foreign policy and its repercussions in the Low Countries.
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Coordinator: UNIVERSITY OF YORK
Country: United Kingdom
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